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Updated: Aug 27, 2025

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
Published on: November 12, 2015
[Virus-induced compartimentalization: aggresomes, cytoplasmic inclusions and viral factories]
Danielle Blondel1, Xavier Lahaye1, Aurore Vidy1
1CNRS, UMR2472, Inra, UMR1157, IFR 115, Virologie moléculaire et structurale, 91198, Gif-sur-Yvette, France.
Abstract:
Some viruses induce, in the infected cells, the formation of cytoplasmic inclusions that are known to contain viral proteins. These viral inclusions that share some characteristics of aggresomes have been considered as sideproducts of the infectious process without any role and resulting from the accumulation and aggregation of large quantities of proteins produced in excess during infection. However, recent results obtained on some viral families suggest that these inclusions have different functions: they can be sites of specific degradation of antiviral proteins or viral factories where essential viral steps (transcription/replication, translation, viral assembly) take place. It is supposed that the viruses-induced compartimentalization is the result of cellular defense mechanisms, which would be diverted by virus for their own replication.
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