Related Experiment Video
Updated: Aug 27, 2025
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
[Cellular receptors and in vivo measles virus propagation]
Boyan Grigorov1, Denis Gerlier1
1CNRS, Université Lyon-I FRE3011, Inserm U758, CERVI, 21, avenue Tony-Garnier, 69007 Lyon, France.
Abstract:
Since the nineties, the analysis of the molecular mechanisms gover- ning the entry of measles virus has strongly impacted our knowledge of viral propagation into tissues during the natural infection. The identification of cellular receptors and the 3D structure of the viral glycoprotein mediating virus attachment have revealed how an RNA virus with error-prone poly- merase has remained immunologically monomorphous despite of more than twenty circulating genotypes around the world. In addition, the neo-targeting towards another cellular receptor suggests its involvement in the attenuation phenotype of the vaccine strains. Likewise, from this virus, the first class of an envelope glycoprotein supporting any retargeting has been developed.
Insights
Understanding measles virus entry mechanisms reveals how this RNA virus maintains immune stability despite genetic diversity. Research also suggests a link between receptor targeting and vaccine strain attenuation.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Context:
- Measles virus infection mechanisms
- Viral propagation in tissues
- Cellular receptor identification
- Viral glycoprotein structure
Purpose:
- Elucidate molecular mechanisms of measles virus entry
- Investigate viral attachment and tissue propagation
- Understand measles virus's immunological monomorphism
- Explore vaccine strain attenuation
Summary:
- Identification of cellular receptors and viral glycoprotein structure explains measles virus's immunological stability despite genetic variation.
- The error-prone polymerase of this RNA virus has not led to significant antigenic drift.
- Neo-targeting of a cellular receptor suggests a role in the attenuation of measles vaccine strains.
Impact:
- Advanced understanding of viral entry and propagation
- Insights into maintaining viral genetic stability
- Potential for developing novel vaccine strategies
- Development of the first retargeting envelope glycoprotein class from measles virus
Related Concept Videos
01:39Receptor-mediated Endocytosis
01:29Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...