PBA-MoS₂ nanoboxes with enhanced peroxidase activity for constructing a colorimetric sensor array for reducing...

Area of Science:

• Materials Science
• Nanotechnology
• Analytical Chemistry

Background:

• Simultaneous detection of multiple molecules is challenging for existing nanoperoxidase sensors.
• Nickel cobalt Prussian blue analogue-MoS2 nanoboxes (PBA-MoS2) offer enhanced catalytic properties.

Purpose of the Study:

• To develop a novel colorimetric sensing array for simultaneous detection of multiple reductive substances.
• To utilize the peroxidase-like activity of PBA-MoS2 for sensing applications.

Main Methods:

• Hydrothermal synthesis of PBA-MoS2 nanoboxes.
• Construction of a colorimetric sensing array using PBA-MoS2, H2O2, and 3,3,5,5-tetramethylbenzidine (TMB).
• Quantitative analysis using linear discriminant analysis (LDA).

Main Results:

• PBA-MoS2 exhibited excellent peroxidase-like activity, catalyzing TMB oxidation in 2 min.
• The catalytic mechanism involves reactive species like holes (h+) and superoxide radicals (•O2-).
• The sensing array successfully distinguished five reductive substances (catechol, epinephrine hydrochloride, procyanidin, caffeic acid, dopamine hydrochloride) at the 2 mM level based on color changes.

Conclusions:

• PBA-MoS2 nanoboxes are effective nanoperoxidases for constructing a multi-analyte colorimetric sensor.
• The developed sensing array offers a fast, economic, and quantitative method for detecting multiple reductive substances.
• This approach advances simultaneous detection capabilities in analytical chemistry.