Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

272
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
272
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

761
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
761
Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

709
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis.
709
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

273
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
273
Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

741
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
741
Nuclear Overhauser Enhancement (NOE)01:07

Nuclear Overhauser Enhancement (NOE)

794
Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling.  This phenomenon, called the Nuclear Overhauser Enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring...
794

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Risks and Benefits of Synthetic Medical Images.

Radiology·2026
Same author

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study.

medRxiv : the preprint server for health sciences·2026
Same author

Imaging Near Spinal Fixation Hardware at 0.55 T Compared With 3 T.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Neural Shape Modeling Reveals Early and Progressive Femoral Bone Shape and Cartilage Thickness Changes After Anterior Cruciate Ligament Reconstruction.

medRxiv : the preprint server for health sciences·2026
Same author

For want of a nail, region-based qualitative BPE.

European radiology·2026
Same author

Metabolic bone imaging and its relationship with biomechanics.

Osteoarthritis imaging·2026

Related Experiment Video

Updated: Aug 27, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.6K

A method for measuring B0 field inhomogeneity using quantitative double-echo in steady-state.

Marco Barbieri1, Akshay S Chaudhari1,2, Catherine J Moran1

  • 1Department of Radiology, Stanford University, Stanford, California, USA.

Magnetic Resonance in Medicine
|September 26, 2022
PubMed
Summary

A new method uses quantitative Double-Echo in Steady-State (qDESS) for accurate B0 mapping in knee imaging. This technique provides reliable B0 maps comparable to existing methods, potentially shortening MRI protocols.

Keywords:
bilateral knee imagingqDESSqMRI

More Related Videos

Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

12.9K
Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement
09:43

Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement

Published on: November 7, 2017

9.6K

Related Experiment Videos

Last Updated: Aug 27, 2025

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
09:30

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

19.6K
Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

12.9K
Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement
09:43

Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement

Published on: November 7, 2017

9.6K

Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Biomedical Engineering

Background:

  • Accurate B0 mapping is crucial for quantitative MRI, particularly in knee imaging.
  • Existing methods for B0 mapping can add significant time to MRI protocols.

Purpose of the Study:

  • To develop and validate a novel method for B0 mapping using quantitative Double-Echo in Steady-State (qDESS).
  • To exploit the phase difference between qDESS echoes for B0 estimation, independent of the first echo time.

Main Methods:

  • Bloch simulations were used to assess the robustness of the qDESS B0 mapping method.
  • Phantom and in vivo knee imaging studies compared qDESS B0 maps with those from water saturation shift referencing (WASSR) and multi-gradient-echo (GRE) sequences.
  • Quantitative assessment involved pixel-wise difference maps, Bland-Altman analysis, and Lin's concordance coefficient.

Main Results:

  • The qDESS method demonstrated good agreement with WASSR for B0 mapping in both phantoms (concordance coefficient [Formula] = 0.98) and in vivo subjects ([Formula] = 0.90).
  • The agreement between qDESS and WASSR was comparable to that achieved with a 2-GRE method.
  • The proposed method provides inherently co-registered B0 maps.

Conclusions:

  • The developed qDESS B0 mapping method is accurate and reliable for knee imaging.
  • This technique can potentially eliminate the need for separate B0 measurement sequences, shortening overall imaging time.
  • The method offers a more efficient approach to quantitative MRI protocols requiring B0 correction.