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Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review
Alaa Emad Eldeeb1, Salwa Salah2, Nermeen A Elkasabgy2
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. Alaa.ali@pharma.cu.edu.eg.
AAPS Pharmscitech
|September 27, 2022
Summary
Tissue engineering accelerates natural healing using biocompatible scaffolds, including smart biomaterials and 3D/4D printing. This approach offers new solutions for tissue repair and understanding diseases like COVID-19.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Tissue engineering aims to enhance natural healing processes, moving beyond traditional organ transplantation.
- Biodegradable, biocompatible polymers from natural or synthetic sources are crucial for scaffolding in tissue regeneration.
- Smart biomaterials, responsive to external stimuli, are emerging as advanced materials in this field.
Purpose of the Study:
- To review recent applications of diverse biomaterials in tissue engineering.
- To highlight targeted tissues, and key in vitro and in vivo findings.
- To summarize emerging trends like stem cell therapy, 3D, and 4D printing.
Main Methods:
- Review of current literature on biomaterials for tissue engineering.
- Analysis of in vitro and in vivo studies on scaffold applications.
- Discussion of smart biomaterials and advanced fabrication techniques (3D/4D printing).
Main Results:
- Various natural and synthetic polymers are utilized as scaffolds for tissue regeneration.
- Smart biomaterials demonstrate unique responsive properties for dynamic scaffold development.
- Recent trends include stem cell integration and advanced printing technologies for complex tissue structures.
Conclusions:
- Tissue engineering offers promising therapeutic strategies for tissue repair and regeneration.
- Advanced techniques like 4D printing with smart biomaterials mimic natural tissue dynamics.
- These methods hold potential for disease research (e.g., COVID-19) and lung tissue restoration.
