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Updated: Aug 4, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 17, 2013
Early adventures in drug metabolism: 2. The absorption of drugs
Abstract:
This paper deals with our experiences in drug metabolism in the Parke-Davis Research Laboratories at a time when good analytical procedures were just starting to make their appearance and pharmacokinetics was an undiscovered territory. Some of our groping efforts to understand the factors influencing absorption are described. These included formulation differences in generic products and their effect upon absorption. Compounds such as p-aminosalicylic acid, chloramphenicol, phenytoin and acedapsone are used as examples. Our intent is to show how our knowledge of drug metabolism developed during this period, and to describe some areas that still need additional investigation.
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