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Cognitive Development in Lambdoid Craniosynostosis: A Systematic Review and Meta-Analysis
Sarah N Chiang1, Annahita R Fotouhi1, Michelle M Doering2
1Department of Surgery, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Summary
Children with lambdoid craniosynostosis may have slightly lower general cognition scores. However, verbal and psychomotor development show no significant differences, warranting further research.
Area of Science:
- Pediatric Neurosurgery
- Developmental Neuroscience
- Clinical Genetics
Background:
- Lambdoid craniosynostosis, a rare birth defect affecting skull fusion, occurs in approximately 1 in 33,000 live births.
- Surgical correction is common to ensure proper brain growth and head shape.
- The impact of lambdoid craniosynostosis and its surgical treatment on cognitive development remains largely unknown.
Conclusions:
- Lambdoid craniosynostosis patients may exhibit slightly below-average general cognition, but other developmental domains show variable results.
- Small sample sizes limited the analyses.
- Multidisciplinary care and psychological support are recommended; further research with larger cohorts is needed to explore other developmental areas.
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