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Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Esophageal Strictures-II: Clinical Features and Management01:26

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Childhood constipation: Current status, challenges, and future perspectives.

Shaman Rajindrajith1,2, Niranga Manjuri Devanarayana3, Marc A Benninga4

  • 1Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka.

World Journal of Clinical Pediatrics
|October 3, 2022
PubMed
Summary
This summary is machine-generated.

Childhood constipation affects 9.5% globally, impacting quality of life and healthcare costs. Diagnosis uses Rome IV criteria, with treatments ranging from lifestyle changes to medications and advanced therapies for severe cases.

Keywords:
ChildrenConstipationFunctional gastrointestinal disordersPsychological stressSurgical interventionsTreatment

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Public Health

Background:

  • Childhood constipation is a prevalent global health issue, affecting 9.5% of children and imposing significant financial burdens and reduced quality of life.
  • Diagnosis relies on Rome IV criteria, identifying functional constipation through symptom-based evaluation.
  • Risk factors include psychological stress, child abuse, poor diet, inactivity, and altered gut microbiome.

Discussion:

  • The primary mechanism involves stool withholding, with contributions from rectal, anal sphincter, pelvic floor, and colonic dysfunction.
  • Clinical evaluation is paramount; investigations are typically reserved for refractory cases.
  • Treatment encompasses non-pharmacological methods (education, diet, behavior therapy) and pharmacological agents (laxatives, novel drugs).

Key Insights:

  • Functional constipation in children presents diverse clinical signs and significant health impacts.
  • A multifactorial etiology involves psychological, dietary, lifestyle, and physiological factors.
  • Comprehensive management strategies are essential, tailored to individual patient needs.

Outlook:

  • Refractory cases may require advanced interventions like transanal irrigation, botulinum toxin, neuromodulation, or surgery.
  • Probiotic use remains experimental; further research is needed.
  • Preventive measures emphasize healthy diet, active lifestyle, and stress reduction.