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Acremonium keratitis: Risk factors, clinical characteristics, management, and outcome in 65 cases

Smruti Rekha Priyadarshini1, Tanvi Soni1, Srikant Kumar Sahu1

  • 1Cornea and Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, Odisha, India.

Indian Journal of Ophthalmology
|October 3, 2022
PubMed
Abstract

Insights

Acremonium keratitis, a fungal eye infection, is often linked to trauma. Early treatment with antifungals is effective, but older age and delayed treatment increase the risk of poor visual outcomes.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Fungal keratitis is a significant cause of visual impairment globally.
  • Acremonium species are increasingly recognized as causative agents of fungal keratitis.

Purpose of the Study:

  • To investigate risk factors, clinical presentation, management, and outcomes of Acremonium keratitis.
  • To identify predictors of poor visual outcomes in Acremonium keratitis.

Main Methods:

  • Retrospective review of 65 culture-proven Acremonium keratitis cases (2007-2019).
  • Analysis of clinical findings, microbiological investigations, and treatment outcomes.
  • Statistical analysis to identify risk factors for poor visual outcomes.

Main Results:

  • Trauma was the most common predisposing factor (49.2%).
  • Average infiltrate size was 24.8 mm2; hypopyon observed in 43.1% of cases.
  • Age >50 years and treatment delay >15 days were independent risk factors for poor visual outcome (VA <20/60).

Conclusions:

  • Early medical management with topical antifungals is effective for Acremonium keratitis.
  • Advanced or non-responding cases necessitate surgical intervention for infection resolution.
Keywords:
corneal infectionmicrobial keratitis

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