Irrational ophthalmic fixed-dose combinations for dry eye syndrome

Area of Science:

• Ophthalmology
• Pharmacology

Background:

• Dry eye syndrome (DES) incidence is increasing, particularly with digital device use.
• Existing treatments for DES have limitations in efficacy and safety.
• Fixed Dose Combinations (FDCs) pose risks due to potentially irrational or harmful ingredients.

Purpose of the Study:

• To critically evaluate the composition of FDCs marketed for DES in India.
• To raise awareness among prescribers regarding the ingredients, efficacy, and safety of DES FDCs.
• To advocate for informed prescribing practices for dry eye syndrome management.

Main Methods:

• Review of government committee reports on irrational FDCs.
• Analysis of the ingredients in selected FDCs for dry eye syndrome.
• Assessment of the rationale, efficacy, and safety data for included ingredients.

Main Results:

• Some FDCs for DES contain ingredients lacking a clear therapeutic rationale.
• Concerns exist regarding the safety and potential harm of certain FDC components.
• Government committees have identified and recommended the removal of irrational FDCs.

Conclusions:

• Prescribers must be vigilant about the ingredients in FDCs for dry eye syndrome.
• The efficacy and safety data for FDC ingredients require careful consideration.
• Informed prescription of FDCs is crucial for effective and safe dry eye syndrome management.