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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

373
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
373
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

647
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
647
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

395
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
395
Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

292
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
292
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

183
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
183
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

444
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
444

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Formulation and Characterization of Bioactive Agent Containing Nanodisks
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Advanced CaCO3-derived delivery systems for bioactive compounds.

Chen Tan1, Cristian Dima2, Meigui Huang3

  • 1China-Canada Joint Lab of Food Nutrition and Health (Beijing), School of Food and Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.

Advances in Colloid and Interface Science
|October 4, 2022
PubMed
Summary
This summary is machine-generated.

Advanced calcium carbonate (CaCO3) delivery systems overcome limitations like rapid dissolution and poor retention. Recent innovations focus on modified CaCO3 particles and integrated systems for enhanced bioactive compound delivery.

Keywords:
Advanced delivery systemBioactivesCalcium carbonateControlled releaseEncapsulation

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Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Drug Delivery Systems

Background:

  • Calcium carbonate (CaCO3) is a widely available, biocompatible, and degradable material used in delivery systems.
  • Traditional CaCO3 systems face challenges including rapid dissolution in stomach acid, low retention, and lack of sustained release.
  • Modifications and integration with other systems are key to overcoming these limitations.

Purpose of the Study:

  • To review recent advancements (2015-2022) in CaCO3-derived advanced delivery systems.
  • To explore various innovative CaCO3-based encapsulation strategies.
  • To highlight applications and challenges in delivering bioactive compounds.

Main Methods:

  • Review of literature on CaCO3-derived delivery systems from 2015-2022.
  • Categorization of systems including polymer-doped, surface-coated, Pickering emulsions, hydrogels, and liposomal formulations.
  • Analysis of templated systems like hollow, matrix-type, and core-shell capsules.

Main Results:

  • Various advanced CaCO3 systems demonstrate improved properties for controlled release.
  • Polymer-doped, surface-coated, and Pickering emulsion systems show promise.
  • CaCO3-in-hydrogels, liposomal formulations, and templated capsules offer novel delivery platforms.
  • Emerging systems include hollow capsules, matrix-type capsules, and core-shell capsules.

Conclusions:

  • Advanced CaCO3-derived systems offer significant improvements over traditional methods for bioactive compound delivery.
  • These systems show potential in biological, pharmaceutical, and functional food applications.
  • Further research is needed to address specific challenges for each advanced system.