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Updated: Aug 8, 2026

Mitochondrial Ca2+ Retention Capacity Assay and Ca2+-triggered Mitochondrial Swelling Assay
Published on: May 1, 2018
[Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria]
Abstract:
It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein). Mechanism of the effect of oxalacetic acid on permeability of the mitochondria membranes are discussed.
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