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[Research advances in the application of bone metabolic markers in children's diseases associated with growth and

F Yu1, Y M Jiang1

  • 1Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|October 8, 2022
PubMed

Insights

Rising rates of childhood growth disorders are linked to malnutrition and endocrine issues. Bone metabolism markers offer insights for early diagnosis and monitoring of these conditions.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Bone Biology

Background:

  • Childhood growth and development diseases like rickets, obesity, dwarfism, and precocious puberty are increasing.
  • These conditions are often associated with malnutrition and endocrine system disorders in children.
  • Bone serves as a structural framework and is a key endocrine organ and hormone target.

Purpose of the Study:

  • To summarize and comment on the characteristics, classification, and applications of bone metabolism markers.
  • To provide a reference for the prevention, early diagnosis, and treatment monitoring of pediatric growth and development diseases.

Main Methods:

  • Literature review and synthesis of existing studies on bone metabolism markers.
  • Analysis of marker changes in various pediatric growth and development diseases.
  • Commentary on the clinical utility of these markers.

Main Results:

  • Bone metabolism markers' levels change significantly in children's growth and development diseases.
  • These markers are crucial for understanding bone formation and resorption processes.
  • Specific markers show distinct patterns related to different pediatric endocrine and nutritional disorders.

Conclusions:

  • Bone metabolism markers are valuable tools for managing pediatric growth and development diseases.
  • Understanding these markers aids in early detection and effective treatment monitoring.
  • Further research into bone metabolism markers can improve pediatric healthcare outcomes.

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