New markers in metabolic syndrome
Da-Hye Son1, Hyun-Su Ha2, Hye-Min Park3
1Department of Family Medicine, Yonsei University College of Medicine, Seoul, South Korea; Department of Integrative Medicine, Yonsei University Graduate School, Seoul, South Korea.
Advances in Clinical Chemistry
|October 9, 2022
Summary
Metabolic syndrome (MetS) is a growing global health concern linked to serious diseases. This review details key biomarkers for MetS diagnosis and management, focusing on laboratory analysis.
Area of Science:
- Endocrinology and Metabolism
- Clinical Biochemistry
- Public Health
Background:
- Metabolic syndrome (MetS) prevalence is rising globally, posing significant clinical risks.
- Central obesity-driven insulin resistance and chronic inflammation are key pathophysiological factors.
- MetS is associated with increased risks of cardiovascular disease, type 2 diabetes, and cancer.
Purpose of the Study:
- To provide a comprehensive overview of established and emerging biomarkers for Metabolic syndrome.
- To discuss the diagnostic utility of various biochemical markers in MetS.
- To propose a systematic approach for laboratory analysis in MetS assessment.
Main Methods:
- Literature review of current research on Metabolic syndrome biomarkers.
- Analysis of established and proposed laboratory markers, including insulin resistance indices, adipokines, inflammatory markers, uric acid, alkaline phosphatase, and γ-glutamyl transferase.
- Synthesis of information regarding the correlation of these markers with MetS.
Main Results:
- Insulin resistance indices, adipokines, and inflammatory markers are widely accepted biomarkers for MetS.
- Uric acid, alkaline phosphatase, and γ-glutamyl transferase show positive correlations with MetS and potential diagnostic value.
- A systematic laboratory approach can aid in the reliable assessment of MetS.
Conclusions:
- Accurate identification of MetS biomarkers is crucial for early diagnosis and intervention.
- A multi-marker laboratory approach enhances the diagnostic capability for Metabolic syndrome.
- Further research into novel biomarkers and standardized analysis protocols is warranted.
More Related Videos
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
46
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
46
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
189
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
189
01:24Obesity
585
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
585
01:19Regulation of Metabolism
9.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.8K
01:29Cholesterol: Significance and Regulation
646
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
646
01:24Overview of Lipid Metabolism
2.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.1K