Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.4K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.4K
Neuroplasticity01:01

Neuroplasticity

697
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
697
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.5K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Fear learning in unmedicated patients with anxiety disorders: a comparison of delay conditioning, fear reversal, and trace conditioning.

Translational psychiatry·2026
Same author

Disrupted Higher-Order Topology in OCD Brain Networks Revealed by Hodge Laplacian - an ENIGMA Study.

bioRxiv : the preprint server for biology·2026
Same author

Executive Function in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same journal

Vowel acoustic parameters in speech assessment and rehabilitation of minimally verbal and speech-motor-impaired autistic children: a narrative review.

Frontiers in human neuroscience·2026
Same journal

Toward clinical translation of TMS-EEG: an integrative review of multidimensional neurophysiological measures.

Frontiers in human neuroscience·2026
Same journal

The causal efficacy of consciousness: a neuroscientific analysis and explanation.

Frontiers in human neuroscience·2026
Same journal

Temporal-oscillatory entrainment: a multi-timescale framework for rhythmic coordination from neural to social frequencies.

Frontiers in human neuroscience·2026
Same journal

Role of AQP4 in ameliorating heat stress-induced cellular injury in a cell line model through active heat acclimation.

Frontiers in human neuroscience·2026
Same journal

Correction: Cognitive state monitoring for neuroadaptive information visualization.

Frontiers in human neuroscience·2026
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.3K

Complexity changes in functional state dynamics suggest focal connectivity reductions.

David Sutherland Blair1, Carles Soriano-Mas2,3,4, Joana Cabral5

  • 1Facultad de Comunicación, Universitat Pompeu Fabra, Barcelona, Spain.

Frontiers in Human Neuroscience
|October 10, 2022
PubMed
Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) is linked to increased brain activity complexity. A new method reveals higher global and regional complexity in OCD patients, suggesting cognitive disorder and altered cortical connectivity.

Keywords:
Hopf bifurcationLEiDAShannon entropyeigendecompositionindependent component analysisnetwork-based statisticobsessive-compulsive disorderwhole-brain model

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K

Related Experiment Videos

Last Updated: Aug 26, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.3K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.3K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K

Area of Science:

  • Computational Neuroscience
  • Neuroimaging
  • Psychiatric Research

Background:

  • Neuroscience research has expanded significantly, with complexity research gaining prominence.
  • Previous studies suggest psychiatric disorders alter brain activity complexity, but often overlook distributed cognition.
  • This limitation can lead to inaccurate interpretations of global and regional entropy estimates.

Purpose of the Study:

  • To introduce a novel method for estimating brain activity complexity that accounts for distributed cognition.
  • To apply this method to analyze brain activity in individuals with obsessive-compulsive disorder (OCD).

Main Methods:

  • Developed a new complexity estimation method by projecting dynamic functional connectivity into a low-dimensional space.
  • Estimated dimension-specific entropy within this space for rapid global signal complexity assessment.
  • Utilized a Hopf oscillator-based model to estimate subject-level effective connectivity.

Main Results:

  • Obsessive-compulsive disorder patients exhibited significantly increased global and dimension-specific brain activity complexity compared to healthy controls.
  • Analysis suggested that OCD patients may experience greater cognitive disorder.
  • Effective connectivity analysis indicated abnormally high connectivity across a broad cortical network in OCD patients.

Conclusions:

  • The novel method is robust and sensitive for detecting group-level complexity alterations in brain activity.
  • Findings suggest that OCD is associated with increased brain activity complexity and altered cortical connectivity.
  • The proposed method offers a more accurate approach to assessing brain complexity in psychiatric disorders.