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Published on: January 29, 2016
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Physical activity and risk of multiple sclerosis: A Mendelian randomization study
Chunyu Li1, Junyu Lin1, Tianmi Yang1
1Department of Neurology, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in Immunology
|October 10, 2022
Summary
Engaging in moderate physical activity is linked to a lower risk of developing multiple sclerosis (MS). This study used genetic analysis to confirm that regular exercise may be a protective lifestyle factor against MS.
Area of Science:
- Neuroepidemiology
- Genetics
- Public Health
Background:
- Epidemiological studies suggest a link between physical activity and multiple sclerosis (MS) risk, but findings are inconsistent.
- The causal relationship and confounding factors remain unclear.
Purpose of the Study:
- To investigate the role of different intensities of physical activity in MS risk.
- To evaluate the potential causal association using genetic methods.
Main Methods:
- Estimated genetic correlation between physical activity and MS risk.
- Conducted two-sample and multivariable Mendelian randomization analyses.
- Utilized large genome-wide association study summary statistics.
Main Results:
- A significant negative genetic correlation was found between moderate physical activity and MS risk (r = -0.15, P = 0.0029).
- Higher moderate physical activity showed a significant association with reduced MS risk (OR = 0.87, P = 0.00345).
- Findings were consistent across sensitivity analyses and validated with overall physical activity data (OR = 0.36, P = 0.00682).
Conclusions:
- Moderate physical activity appears to reduce the risk of multiple sclerosis.
- These findings support physical activity as a potential lifestyle recommendation for MS prevention.
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