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Updated: Aug 26, 2025
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Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
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A Method for Assessing Stability of Regional Blood Circulation in Humans.
1P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. l.v.mezentseva@mail.ru.
Bulletin of Experimental Biology and Medicine
|October 10, 2022
Summary
A novel non-invasive method assesses human regional circulatory system stability using laser Doppler flowmetry and mathematical analysis. This technique evaluates circulatory reserve capacity and predicts vascular pathology risks for personalized patient care.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Medical Diagnostics
Background:
- Assessing the human regional circulatory system's stability is crucial for diagnosing vascular pathologies.
- Current methods may lack the precision or non-invasiveness required for comprehensive evaluation.
- Understanding regional blood flow dynamics is key to predicting cardiovascular risks.
Purpose of the Study:
- To develop and validate a novel non-invasive method for assessing the stability of the human regional circulatory system.
- To enhance the informative value of circulatory studies through advanced mathematical analysis.
- To enable personalized risk assessment for vascular pathologies.
Main Methods:
- Synchronous laser Doppler flowmetry measurements of cutaneous blood microcirculation in symmetrical organ areas.
- Original computational and experimental technique for mathematical analysis of Dopplerograms.
- Utilizing a mathematical model based on differential equations to describe left-right asymmetry in circulatory oscillatory processes.
Main Results:
- Successful development of a non-invasive method for assessing regional circulatory system stability.
- Demonstrated ability to evaluate the reserve capabilities of the regional circulatory system.
- Increased informative value of circulatory studies compared to existing methods.
Conclusions:
- The proposed method offers a reliable, non-invasive approach for personalized assessment of regional blood circulation stability.
- This technique can significantly aid in predicting the risks of developing vascular pathologies.
- The method holds promise for widespread clinical application in cardiovascular diagnostics.
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