Related Experiment Video
Updated: Aug 26, 2025
Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Time-course of age-related temporal order memory decline in an object recognition paradigm in mice
Hassina Belblidia1, Thomas Freret2, Marianne Leger2
1Normandie Univ, UNICAEN, INSERM, CYCERON, CHU Caen, COMETE UMR 1075, 14000 Caen, France; Université M'hamed Bougara UMBB, Faculté des Sciences, 35000 Boumerdès, Algeria.
Abstract:
Temporal order memory refers to the ability to remember the order of occurrence of items across time. It is a critical feature of episodic memory that is often tested in rodents using spontaneous object recognition paradigms. However, impact of aging over performances of temporal order memory decline is barely known. Herein, we characterized here the effect of normal aging on the temporal order memory performances in NMRI mice between 3 and 19months of age, with an inter-session interval of 24h.We found that temporal order memory was impaired as soon as7 months of age. These results provide strong evidence that temporal order memory is particularly vulnerable to the deleterious effect of normal aging.
