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Updated: Aug 26, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Glucose variability is a marker for COVID-19 severity and mortality
Ran Abuhasira1,2, Alon Grossman1,3
1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
High glucose variability in hospitalized COVID-19 patients may indicate higher mortality risk, but this link weakens with clinical data adjustments. Glucose coefficient of variation (CV) is a potential simple marker for disease severity.
Area of Science:
- Endocrinology
- Infectious Diseases
- Critical Care Medicine
Background:
- Glucose dysregulation is common in hospitalized patients.
- The impact of glucose variability on COVID-19 outcomes requires further investigation.
Purpose of the Study:
- To examine the association between glucose coefficient of variation (CV) and mortality and disease severity in hospitalized COVID-19 patients.
Main Methods:
- Retrospective cohort study of 565 COVID-19 patients.
- Patients stratified by diabetes mellitus (DM) status and quartiles of glucose CV.
- Outcomes included length of stay and in-hospital mortality.
Main Results:
- Higher glucose CV was initially associated with longer hospitalization and mortality in patients with DM.
- Adjustments for comorbidities and laboratory markers attenuated these associations.
- The association between glucose CV and adverse outcomes disappeared after full adjustment.
Conclusions:
- While glucose CV may initially appear linked to COVID-19 severity, this association is confounded by other clinical factors.
- Glucose CV's utility as an independent marker for mortality and severity in COVID-19 is questionable after comprehensive adjustment.
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