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Glucose variability is a marker for COVID-19 severity and mortality

Ran Abuhasira1,2, Alon Grossman1,3

  • 1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Archives of Endocrinology and Metabolism
|October 11, 2022
PubMed

Insights

High glucose variability in hospitalized COVID-19 patients may indicate higher mortality risk, but this link weakens with clinical data adjustments. Glucose coefficient of variation (CV) is a potential simple marker for disease severity.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Glucose dysregulation is common in hospitalized patients.
  • The impact of glucose variability on COVID-19 outcomes requires further investigation.

Purpose of the Study:

  • To examine the association between glucose coefficient of variation (CV) and mortality and disease severity in hospitalized COVID-19 patients.

Main Methods:

  • Retrospective cohort study of 565 COVID-19 patients.
  • Patients stratified by diabetes mellitus (DM) status and quartiles of glucose CV.
  • Outcomes included length of stay and in-hospital mortality.

Main Results:

  • Higher glucose CV was initially associated with longer hospitalization and mortality in patients with DM.
  • Adjustments for comorbidities and laboratory markers attenuated these associations.
  • The association between glucose CV and adverse outcomes disappeared after full adjustment.

Conclusions:

  • While glucose CV may initially appear linked to COVID-19 severity, this association is confounded by other clinical factors.
  • Glucose CV's utility as an independent marker for mortality and severity in COVID-19 is questionable after comprehensive adjustment.
Abstract

Keywords:
COVID-19Glucose variabilityhyperglycemia hospital management

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