Related Experiment Video
Updated: Aug 26, 2025

07:50
Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
14.5K
Backstepping Synchronization Control for Three-Dimensional Chaotic Oscillatory System via DNA Strand Displacement
IEEE Transactions on Nanobioscience
|October 12, 2022
Summary
This study introduces a novel 3D DNA chaotic system and backstepping controllers for synchronization using DNA strand displacement, advancing chaotic dynamics in biochemical networks.
Area of Science:
- Biochemical Engineering
- Chaos Theory
- Synthetic Biology
Background:
- Previous research focused on coupled synchronization of chaotic systems in DNA-based networks.
- Limited studies explored backstepping synchronization control using DNA strand displacement for chaotic systems.
Purpose of the Study:
- To develop a backstepping synchronization control approach for a three-dimensional chaotic system utilizing DNA strand displacement.
- To present a novel three-dimensional DNA chaotic system based on DNA reaction modules and mass action kinetics.
Main Methods:
- Designed four basic strand displacement reaction modules leveraging DNA programming properties.
- Constructed a novel three-dimensional DNA chaotic system using these modules and mass action kinetics.
- Developed three synchronous controllers based on backstepping control theory and DNA reaction modules to achieve synchronization.
Main Results:
- Successfully designed a novel three-dimensional DNA chaotic system.
- Developed backstepping controllers to ensure synchronization between two such systems.
- Numerical simulations confirmed the effectiveness and applicability of the proposed control strategy.
Conclusions:
- The developed backstepping synchronization control approach is valid and applicable for three-dimensional chaotic systems implemented via DNA strand displacement.
- This work contributes to the field of chaotic dynamics and its implementation in synthetic biological systems.
Related Concept Videos
Lagging Strand Synthesis
54.0K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
54.0K
Restarting Stalled Replication Forks
5.9K
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.9K
The DNA Replication Fork
36.5K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork. Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
36.5K
The Replisome
34.5K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
34.5K
DNA Damage can Stall the Cell Cycle
9.3K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.3K
Conservative Site-specific Recombination and Phase Variation
6.1K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...
6.1K

