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Anorectal Testing for Mpox Virus Infection in Men Who Have Sex With Men With and Without Proctitis
Eric A Meyerowitz1, Inessa Gendlina1, Vimi J Desai1
1Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.
Anorectal testing detected mpox virus (MPXV) DNA in most men who have sex with men with MPXV symptoms, even without proctitis. Further research into anorectal testing can improve mpox diagnosis and understanding.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- Mpox virus (MPXV) infection presents with diverse symptoms.
- Anorectal symptoms are common in mpox outbreaks, particularly among men who have sex with men (MSM).
- The role of anorectal testing in diagnosing mpox requires further investigation.
Purpose of the Study:
- To evaluate the utility of anorectal testing for detecting mpox virus DNA.
- To determine the prevalence of rectal MPXV DNA in symptomatic MSM, with and without proctitis.
Main Methods:
- Anorectal testing was performed on 18 cis-gender men who have sex with men presenting with symptoms suggestive of MPXV infection.
- Rectal swabs were analyzed for the presence of MPXV DNA.
Main Results:
- Rectal MPXV DNA was detected in 9 out of 9 individuals with proctitis.
- Rectal MPXV DNA was also detected in 7 out of 9 individuals without proctitis.
Conclusions:
- Anorectal testing is a valuable tool for detecting mpox virus, even in the absence of proctitis.
- Further studies on anorectal testing are crucial for understanding mpox pathogenesis and improving diagnostic strategies.
- These findings highlight the importance of considering anorectal testing in the clinical evaluation of symptomatic MSM during mpox outbreaks.
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