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Multiple Evanescent White Dot Syndrome Following COVID-19 mRNA Vaccination
Mohamed Ali Gargouri1, Naoufel Yousfi1, Jonathan Toutain1
1Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
Purpose:
To report two cases of multiple evanescent white dot syndrome (MEWDS) following COVID-19 vaccination with the BNT162b2 mRNA vaccine.
Methods:
Two case reports. Case-1: A 40-yo Caucasian male, complained of blurred and decrease of vision in his left eye (OS) one week after the first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine. Funduscopic examination OS showed multiple granular white dots with an aspect of foveal granularity. Case-2: A 23-yo woman also presented with defective and decrease of vision OS. She received her first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine ten days before. Dilated fundus examination OS showed altered macular reflex with an aspect of foveal granularity.
Results:
Multimodal imaging showed features of MEWDS in both cases. The anomalies found resolved spontaneously after 6 weeks.
Conclusion:
Inflammation and immune dysregulation induced by COVID-19 mRNA vaccine or its adjuvants could be involved in ocular adverse effects.
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