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Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without
Kylie Kavanagh1,2,3, Alexander C Bashore3, Matthew A Davis3
1Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Obesity (Silver Spring, Md.)
|October 14, 2022
Summary
Early time-restricted feeding (eTRF) improved cholesterol efflux capacity in nonhuman primates. This dietary strategy may offer cardiovascular benefits by enhancing high-density lipoprotein function.
Area of Science:
- Metabolic health and aging research.
- Cardiovascular disease (CVD) risk factor modification.
- Chronobiology and nutritional interventions.
Background:
- Time-restricted feeding (TRF) is a dietary approach that limits caloric intake to a specific window.
- Early TRF (eTRF) aligns eating patterns with the body's natural circadian rhythms.
- TRF shows potential for improving metabolic syndrome and cardiovascular disease risk, especially in aging and obese individuals.
Purpose of the Study:
- To investigate the efficacy of eTRF in raising high-density lipoprotein (HDL) cholesterol levels.
- To assess the impact of eTRF on plasma cholesterol efflux capacity (CEC), a key indicator of cardiovascular health.
- To examine these effects in an aging nonhuman primate (NHP) model.
Main Methods:
- Adult and geriatric nonhuman primates (NHPs) were assigned to either ad libitum feeding or eTRF for 12 months.
- Measurements included body composition, glycemic control, plasma HDL cholesterol, and CEC.
- CEC was assessed, focusing on efflux to HDL particles.
Main Results:
- Geriatric NHPs exhibited impaired CEC.
- eTRF led to the formation of larger HDL particles and increased HDL apolipoprotein A-1 content.
- Plasma CEC, primarily to HDL particles, was significantly increased in both adult and geriatric NHPs following eTRF, without altering glycemic control or body composition.
Conclusions:
- eTRF demonstrated a beneficial effect in enhancing HDL cholesterol efflux capacity in nonhuman primates.
- This suggests eTRF may be a viable strategy to improve cardiovascular health markers, particularly in aging populations.
- The findings support the role of circadian-aligned eating in metabolic and cardiovascular well-being.
