Related Experiment Video
Updated: Aug 25, 2025
Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
Improved Macro- and Micronutrient Supply for Favorable Growth and Metabolomic Profile with Standardized Parenteral
Alida Kindt1,2, Yvonne Kraus3,4, David Rasp2
1Institute of Computational Biology, Helmholtz Zentrum München, 85764 Oberschleißheim, Germany.
Insights
A new standardized parenteral nutrition (PN) solution, MUC PREPARE, improved nutrient intake and growth in very preterm infants. This led to earlier feeding cessation and better long-term growth outcomes.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Metabolic Medicine
Background:
- Very preterm infants often experience suboptimal nutrition, leading to poor weight gain and metabolic issues like inadequate bone mineralization.
- Parenteral nutrition (PN) is critical for these infants but traditionally involves individualized, compounded solutions.
- Challenges exist in optimizing nutrient delivery and growth in extremely premature neonates.
Purpose of the Study:
- To evaluate a novel standardized parenteral nutrition (PN) solution, MUC PREPARE, for very preterm infants.
- To compare MUC PREPARE's efficacy against individually prescribed PN solutions regarding nutritional intake, feeding duration, and growth.
- To assess the impact of standardized PN on macro- and micronutrient levels, metabolism, and both short- and long-term growth.
Main Methods:
- A study involving 58 very preterm infants receiving the standardized MUC PREPARE PN solution.
- Comparison of outcomes with a matched historic reference group (58 infants) receiving individually compounded PN.
- Assessment of macro- and micronutrient intake, electrolyte balance, metabolomic profiles, and growth parameters (weight gain, growth at 2 years).
Main Results:
- Infants on MUC PREPARE showed enhanced macro- and micronutrient intake, leading to balanced electrolytes and stable metabolomic profiles.
- Improved energy supply from MUC PREPARE correlated with earlier cessation of PN (up to 1.5 weeks sooner).
- Significantly higher weight gain (up to 1.9 times) by day 28 in extremely immature infants (<27 weeks GA) and improved overall growth at 2 years.
Conclusions:
- The standardized MUC PREPARE PN solution effectively improved nutritional delivery in very preterm infants.
- MUC PREPARE facilitated earlier discontinuation of PN and promoted superior short- and long-term growth.
- Standardized PN solutions like MUC PREPARE represent a superior therapeutic strategy for optimizing outcomes in very preterm neonates.
Abstract:
Very preterm infants are at high risk for suboptimal nutrition in the first weeks of life leading to insufficient weight gain and complications arising from metabolic imbalances such as insufficient bone mineral accretion. We investigated the use of a novel set of standardized parenteral nutrition (PN; MUC PREPARE) solutions regarding improving nutritional intake, accelerating termination of parenteral feeding, and positively affecting growth in comparison to individually prescribed and compounded PN solutions. We studied the effect of MUC PREPARE on macro- and micronutrient intake, metabolism, and growth in 58 very preterm infants and compared results to a historic reference group of 58 very preterm infants matched for clinical characteristics. Infants receiving MUC PREPARE demonstrated improved macro- and micronutrient intake resulting in balanced electrolyte levels and stable metabolomic profiles. Subsequently, improved energy supply was associated with up to 1.5 weeks earlier termination of parenteral feeding, while simultaneously reaching up to 1.9 times higher weight gain at day 28 in extremely immature infants (<27 GA weeks) as well as overall improved growth at 2 years of age for all infants. The use of the new standardized PN solution MUC PREPARE improved nutritional supply and short- and long-term growth and reduced PN duration in very preterm infants and is considered a superior therapeutic strategy.
More Related Videos
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Related Concept Videos
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
01:28Microbial Nutrition
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...