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Relationship between Ideal Cardiovascular Health and Incident Proteinuria: A 5 Year Retrospective Cohort Study

Yu-Min He1, Wei-Liang Chen1,2,3, Tung-Wei Kao1,2,4

  • 1Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.

Nutrients
|October 14, 2022
PubMed

Insights

Achieving more ideal cardiovascular health (CVH) metrics, such as healthy blood pressure, glucose, and BMI, significantly lowers the risk of developing proteinuria. This highlights CVH metrics as a key strategy for proteinuria prevention.

Area of Science:

  • Nephrology
  • Cardiology
  • Preventive Medicine

Background:

  • Proteinuria is a significant risk factor for chronic kidney disease and cardiovascular events.
  • Cardiovascular health (CVH) metrics encompass lifestyle and clinical factors influencing heart health.
  • The association between the number of ideal CVH metrics and proteinuria risk requires further investigation.

Purpose of the Study:

  • To determine if a greater number of ideal cardiovascular health (CVH) metrics reduces the risk of developing proteinuria.
  • To identify specific CVH metrics that are most protective against proteinuria.

Main Methods:

  • Retrospective cohort study involving 169,366 participants aged 21-75 without prior cardiovascular disease or proteinuria.
  • Assessment of seven CVH metrics: smoking, diet, physical activity, blood pressure, BMI, cholesterol, and fasting glucose.
  • Follow-up for an average of 5 years, with proteinuria assessed by dipstick measurement.

Main Results:

  • A higher number of ideal CVH metrics was associated with a significantly lower risk of incident proteinuria.
  • Ideal blood pressure, fasting glucose, and BMI were strongly associated with reduced proteinuria risk.
  • Lower sodium intake, a component of diet, also demonstrated a protective effect against proteinuria.

Conclusions:

  • The number of ideal CVH metrics is inversely related to the risk of developing proteinuria.
  • Ideal CVH metrics, particularly blood pressure, fasting glucose, and BMI, are important predictors of proteinuria.
  • Promoting adherence to ideal CVH metrics is a viable strategy for preventing proteinuria.

Keywords:
cardiovascular diseasesproteinuriarisk factors

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