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Updated: Aug 25, 2025

A Simplified Technique for Producing an Ischemic Wound Model
Published on: May 2, 2012
The Role of Hyperbaric Oxygen Therapy for the Treatment of Wounds
Merrine Klakeel1, Karen Kowalske1
1Department of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, 5151 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Abstract:
Hyperbaric oxygen (HBO) is a Medicare-approved treatment for a variety of diagnoses including chronic nonhealing wounds and radiation necrosis. Hyperbaric oxygen therapy (HBOT) uses high pressures to saturate hemoglobin and dissolve oxygen into blood plasma to create a hyperoxemic environment to nourish and reverse local tissue injury caused by ischemia and hypoxemia. HBOT is expensive and not without risk; therefore, the underlying etiology for the presenting diagnosis must be adequately treated before starting HBO as an adjunct therapy to get maximum benefit.
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