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Updated: Aug 25, 2025

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Published on: March 18, 2017

G4Atlas: a comprehensive transcriptome-wide G-quadruplex database.

Haopeng Yu¹, Yiman Qi¹, Bibo Yang¹

¹Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

Nucleic Acids Research

|October 16, 2022

Summary

This summary is machine-generated.

G4Atlas is the first database of RNA G-quadruplex (rG4) structures across entire transcriptomes. This resource aids research into rG4s

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Last Updated: Aug 25, 2025

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Area of Science:

Molecular Biology
Genomics
Bioinformatics

Background:

RNA G-quadruplexes (rG4s) are crucial tertiary structures involved in post-transcriptional gene regulation.
Advancements in experimental technologies enable the identification of rG4s in vitro and in vivo.

Purpose of the Study:

To present G4Atlas, the first comprehensive database of transcriptome-wide experimental rG4 data.
To facilitate exploration of rG4 functions in biological processes and enable data-driven research.

Main Methods:

Collation, classification, and visualization of experimental rG4 data from rG4-seq, chemical profiling, and ligand-binding assays.
Inclusion of RNA secondary structure predictions for comparative analysis with identified rG4s.
Data compilation from 82 experimental treatments and 238 samples across ten species.

Main Results:

G4Atlas provides a unified resource for transcriptome-wide rG4 experimental data.
The database integrates diverse experimental methods and species, offering extensive coverage.
Incorporation of secondary structure data allows for the study of structural competition.

Conclusions:

G4Atlas serves as a foundational resource for understanding the biological roles of rG4s.
The database supports future deep learning approaches for analyzing rG4 structural features.