Related Experiment Video
Updated: Aug 25, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Multicriteria decision frontiers for prescription anomaly detection over time
Babak Zafari1, Tahir Ekin2, Fabrizio Ruggeri3
1Mathematics and Science Division, Babson College, Babson Park, MA, USA.
Abstract:
Health care prescription fraud and abuse result in major financial losses and adverse health effects. The growing budget deficits of health insurance programs and recent opioid drug abuse crisis in the United States have accelerated the use of analytical methods. Unsupervised methods such as clustering and anomaly detection could help the health care auditors to evaluate the billing patterns when embedded into rule-based frameworks. These decision models can aid policymakers in detecting potential suspicious activities. This manuscript proposes an unsupervised temporal learning-based decision frontier model using the real world Medicare Part D prescription data collected over 5 years. First, temporal probabilistic hidden groups of drugs are retrieved using a structural topic model with covariates. Next, we construct combined concentration curves and Gini measures considering the weighted impact of temporal observations for prescription patterns, in addition to the Gini values for the cost. The novel decision frontier utilizes this output and enables health care practitioners to assess the trade-offs among different criteria and to identify audit leads.
Related Concept Videos
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Analysis of Population Pharmacokinetic Data
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...

