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The Link between ANRIL Gene RS4977574 Polymorphism and Common Atherosclerosis Cardiovascular Complications: A

Polina V Kniazkova1, Viktoriia Yu Harbuzova1, Vladyslav V Pokhmura1

  • 1Department of Physiology and Pathophysiology with Medical Biology Course, Medical Institute of the Sumy State University, Sumy 40034, Ukraine.

Biomed Research International
|October 17, 2022
PubMed

Insights

The ANRIL rs4977574-GG genotype is linked to increased atherosclerosis and cardiovascular risks. This genetic marker may predict complications, particularly in the Ukrainian population.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Atherosclerosis and cardiovascular complications pose significant health challenges.
  • Genetic factors play a crucial role in the development of these conditions.
  • The ANRIL gene is implicated in cardiovascular disease risk.

Purpose of the Study:

  • To investigate the association between the ANRIL rs4977574 polymorphism and the risk of atherosclerosis and cardiovascular complications.
  • To explore the relationship between this polymorphism and lipid profiles.
  • To determine the potential of rs4977574 as a genetic marker in a Ukrainian population.

Main Methods:

  • Case-control study involving patients with acute coronary syndrome (ACS), patients with large artery stenosis (LAS), and healthy controls.
  • Real-time PCR for ANRIL rs4977574 genotyping.
  • Statistical analysis using SPSS software.

Main Results:

  • A significant association was found between the rs4977574 polymorphism and the risk of atherosclerosis and cardiovascular complications under a recessive model (OR = 1.551, p = 0.025).
  • The polymorphism was also linked to altered serum levels of total cholesterol (p = 0.021) and LDL (p = 0.022).
  • Specifically, the rs4977574 polymorphism was associated with an increased risk of ACS (OR = 1.501, p = 0.048) but not LAS (p > 0.05).

Conclusions:

  • The ANRIL rs4977574-GG genotype may serve as a genetic marker for atherosclerosis and cardiovascular complications.
  • This finding holds potential significance for risk stratification and personalized medicine in the Ukrainian population.
  • Further research is warranted to elucidate the precise mechanisms underlying this association.
Abstract

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