The Link Between VDR Gene rs7975232 Polymorphism and Benign Proliferative Breast Disease in Ukrainian Population

We are aimed at examining the potential link between the VDR gene polymorphism rs7975232 and the occurrence of benign breast disease in the Ukrainian population.

One hundred and six patients with BBD and 221 control subjects were enrolled in this case-control study. PCR-RFLP was used for VDR gene rs7975232 genotyping. SPSS software package (Version 25.0, IBM, USA) was used for data analysis.

There was a research relationship between the rs7975232 polymorphism and BPBD and other influencing factors as family history burden, predisposing factors, and blood estradiol levels, smoking, gynecological pathology, hormone intake, goiter, or mastodynia. In individuals younger than 40, heterozygotes have a higher BPBD risk compared with both homozygotes (p = 0.04), but this risk is not statistically significant after adjusting for BMI (p = 0.16). Conversely, for those aged 40 and above, heterozygotes have a lower BPBD risk compared with both homozygotes (p = 0.036), and this significant association remains after BMI adjustment (p = 0.012); additionally, recessive allele homozygotes have a higher BPBD risk compared wiht major allele carriers post-BMI adjustment (p = 0.033).

Obtained data suggested that rs7975232 polymorphism of the VDR gene can be a possible genetic marker for the development of benign proliferative breast disease in the Ukrainian population.