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Updated: Aug 24, 2025
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
[The use of photodynamic therapy in patients with severe forms of leukoplakia]
O F Rabinovich1, I M Rabinovich1, K V Umarova1
1Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Objective:
The aim the study is to increase the effectiveness of the treatment of severe forms of leukoplakia with the use of photodynamic therapy.
Material And Methods:
120 patients with severe forms of leukoplakia were examined. 30 patients were diagnosed with Cr and carcinoma in situ, and therefore they were excluded from the study. In 90 patients, the diagnosis was confirmed by histological and IHC studies. Before the use of photodynamic therapy, the degree of saturation of pathological foci with a photosensitizer was determined by the method of fluorescent diagnostics using the LED device «RFS-400».
Results:
As a result of treatment with photodynamic therapy using a 2nd generation photosensitizer («Photoditazine» 0.5% gel penetrator), a significant improvement in the epithelization of lesion elements was observed: in 92% of patients with verrucous leukoplakia and in 83% of patients with erosive leukoplakia.
Conclusion:
The use of photodynamic therapy for the treatment of patients with complicated forms of leukoplakia is an effective method of treatment for this pathology.
