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Bio-macromolecular design roadmap towards tough bioadhesives
Hossein Montazerian1,2,3, Elham Davoodi1,2,3,4, Avijit Baidya5
1Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90095, USA. psw@cnsi.ucla.edu.
Chemical Society Reviews
|October 21, 2022
Summary
This review outlines a biomacromolecular design strategy for creating tough, adhesive surgical sealants. It explores materials and methods to enhance cohesion and adhesion for improved wound closure and device attachment.
Area of Science:
- Biomaterials Science
- Surgical Sealants
- Wound Management
Background:
- Sutureless wound closure techniques are revolutionizing wound management.
- Advanced biomaterials provide biocompatible platforms for bleeding control and device attachment.
- Tough bioadhesion relies on combined cohesive and adhesive properties.
Purpose of the Study:
- To present a biomacromolecular design roadmap for developing tough, adhesive surgical sealants.
- To review materials and methods for enhancing biomaterial toughness and adhesion.
- To highlight future research opportunities in bioadhesive surgical sealants.
Main Methods:
- Leveraging intrinsically tough and elastic polymers with dynamic intermolecular interactions.
- Introducing strong but reversible bonds via polymer chain design or crosslink additives.
- Promoting underwater adhesion through covalent/noncovalent bonds and micro/macro-interlocking mechanisms.
Main Results:
- Discusses various materials and functional additives for achieving toughness and adhesion.
- Reviews characterization methods for evaluating bioadhesive properties.
- Emphasizes the need for standardized reporting for fair material comparisons.
Conclusions:
- A comprehensive design strategy for tough bioadhesive surgical sealants is presented.
- The review identifies key approaches for enhancing biomaterial performance in wound closure.
- Future research directions are outlined for advancing the field of surgical sealants.
