Diagnosing Multiple Myeloma and Related Disorders
1Department of Microbiology, Immunology and Pathology, Colorado State University, 311 Diagnostic Medical Center, 300 West Drake, Fort Collins, CO 80523-1644, USA.
The Veterinary Clinics of North America. Small Animal Practice
|October 21, 2022
Summary
This review covers myeloma-related disorders, including multiple myeloma and related plasma cell neoplasms. It details diagnostic methods like flow cytometry and histopathology for characterizing these conditions.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Myeloma-related disorders are neoplasms of immunoglobulin (Ig) secreting plasma cells.
- This group includes multiple myeloma, plasmacytomas, Waldenström macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Purpose of the Study:
- To provide current information on various myeloma-related disorders.
- To outline and discuss the diagnostic procedures used for these conditions.
Main Methods:
- Review of current literature on myeloma-related disorders.
- Discussion of diagnostic techniques including cytopathology, histopathology, and flow cytometry.
- Explanation of polymerase chain reaction for antigen receptor rearrangement and electrophoretic techniques.
Main Results:
- Comprehensive overview of multiple myeloma and related plasma cell neoplasms.
- Detailed description of diagnostic procedures for accurate characterization.
- Information on extramedullary plasmacytoma, solitary osseous plasmacytoma, Waldenström macroglobulinemia, and monoclonal gammopathy of undetermined significance.
Conclusions:
- Accurate diagnosis of myeloma-related disorders relies on a combination of methods.
- Understanding these diverse plasma cell neoplasms is crucial for patient management.
- The review consolidates key diagnostic approaches for these hematologic malignancies.
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