Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Irisin has been proposed to have a beneficial influence on the metabolic status of animals and humans. However, the relationship between circulating irisin levels and the risks of metabolic components in humans remains unclear. In the present meta-analysis, we aimed to evaluate the association between circulating irisin and metabolic parameters in nonobese, nondiabetic adults.

We searched PubMed, Embase, the Cochrane Library, Web of Science and ClinicalTrial.gov using the main search terms and identified original articles published prior to March 7, 2022. Studies that met our inclusion criteria and reported the association between irisin and metabolic parameters were included in our meta-analysis. We used the Newcastle Ottawa scale to assess the quality of the included studies.

A total of 14 studies (711 subjects) in 11 articles were included for qualitative and quantitative synthesis. The pooled results showed that circulating irisin was positively and significantly correlated with fasting blood glucose (r = 0.159), HOMA-IR (r = 0.217) and waist-to-hip ratio (WHR) (r = 0.168). However, no significant association was detected between irisin levels and other metabolic parameters.

Thus, these findings indicated the possible link between irisin levels and part of the metabolic parameters in apparently metabolically normal individuals. However, the regulation of irisin in metabolism in humans remains to be fully elucidated, and well-designed prospective studies will be needed in the future. Trial registration The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42022315269.