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Mycobacterium tuberculosis genetic features associated with pulmonary tuberculosis severity

Charlotte Genestet1, Guislaine Refrégier2, Elisabeth Hodille1

  • 1CIRI - Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon-1, Rhône-Alpes, Lyon, France; Hospices Civils de Lyon, Institut des Agents Infectieux, Laboratoire de bactériologie, Rhône-Alpes, Lyon, France.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|October 23, 2022
PubMed
Summary

Genetic features of Mycobacterium tuberculosis (Mtb) influence tuberculosis (TB) severity. Specific Mtb mutations and microdiversity correlate with disease progression, offering potential new prognostic tools for TB.

Keywords:
Genetic heterogeneityGenome-wide association studyMycobacterium tuberculosisPulmonary tuberculosisStructural equation modelingWhole genome sequencing

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