Menorrhagia due to myometrial hypertrophy: treatment with tamoxifen

A unique case is presented of a 23-year-old nulliparous woman with severe menorrhagia, a grossly enlarged uterus, and pure myometrial hypertrophy, confirmed by full-thickness biopsy. Her condition eventually responded to continuous oral therapy with the antiestrogen tamoxifen, and the uterus returned to normal size after nine months of treatment.