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Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters
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Evolution of Electrospinning in Liver Tissue Engineering.

Ashwini Vasudevan1, Dinesh M Tripathi1, Subramanian Sundarrajan2

  • 1Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.

Biomimetics (Basel, Switzerland)
|October 24, 2022
PubMed
Summary

Liver tissue engineering aims to replicate liver cell functions using nanofibrous scaffolds. Electrospinning techniques and scaffold modifications enhance hepatocyte growth and long-term viability ex vivo.

Keywords:
electrospinningextracellular matrix proteinshepatocytesliver tissue engineeringnanofibersnatural and synthetic polymers

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Hepatology

Background:

  • Liver tissue engineering seeks to restore liver cell phenotype and function ex vivo.
  • Biological scaffolds are crucial for supporting hepatocyte growth and differentiation.
  • Nanofibrous scaffolds mimic the native extracellular matrix (ECM) with high surface area and porosity.

Purpose of the Study:

  • To review electrospinning techniques for liver cell scaffold development.
  • To highlight the use of various polymers and ECM in scaffold fabrication.
  • To discuss modifications enhancing hepatocyte long-term growth and viability.

Main Methods:

  • Review of electrospinning techniques for scaffold fabrication.
  • Analysis of synthetic and natural polymers used in scaffolds.
  • Examination of liver extracellular matrix incorporation.
  • Discussion of scaffold modifications like galactosylation and protein incorporation.

Main Results:

  • Electrospinning is a preferred method for producing nanofibrous scaffolds.
  • Scaffolds fabricated from diverse polymers and ECM support liver cell culture.
  • Scaffold modifications significantly improve primary hepatocyte long-term growth and viability.

Conclusions:

  • Electrospun nanofibrous scaffolds are promising for liver tissue engineering.
  • Tailored scaffold design and modifications are key to successful hepatocyte culture.
  • Advanced scaffold strategies promote the functional restoration of liver cells ex vivo.