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Molecularly Imprinted Ratiometric Fluorescence Nanosensors
1CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Shandong Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Molecularly imprinted ratiometric fluorescence (MIR-FL) nanosensors offer high selectivity and sensitivity. This perspective explores challenges and future prospects for developing advanced MIR-FL nanosensors with improved performance and broader applications.
Area of Science:
- Analytical Chemistry
- Materials Science
- Nanotechnology
Background:
- Molecularly imprinted ratiometric fluorescence (MIR-FL) nanosensors are popular due to their selectivity, sensitivity, and portability.
- Current limitations include fluorescence intensity, nanostructure, color range, and practical application challenges.
- New strategies are needed to overcome these difficulties and expand the use of MIR-FL nanosensors.
Purpose of the Study:
- To highlight current research challenges in constructing MIR-FL nanosensors.
- To discuss future prospects for MIR-FL nanosensor development and applications.
- To focus on advancements in dual- and triple-emission modes, postimprinting strategies, microdevices, and multitarget detection.
Main Methods:
- Review and analysis of recent advancements in MIR-FL nanosensor technology.
- Exploration of postimprinting mixing/modification strategies.
- Investigation of microdevice integration and multitarget detection capabilities.
Main Results:
- Identified key challenges in fluorescence intensity, nanostructure, color range, and practical applications.
- Highlighted the potential of dual- and triple-emission modes for enhanced sensing.
- Proposed strategies for technology synergy, improved sensitivity and reproducibility, and increased application diversity and portability.
Conclusions:
- MIR-FL nanosensors hold significant promise for advanced sensing applications.
- Overcoming current limitations requires innovative strategies and technological integration.
- Future research should focus on improving performance, expanding applications, and enhancing device portability.
