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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Biohybrid Micro- and Nanorobots for Intelligent Drug Delivery.

Jinhua Li1,2, Lukas Dekanovsky2, Bahareh Khezri2

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Biohybrid micro- and nanorobots combine biological and artificial parts for medical tasks. This review explores their use in smart drug delivery, highlighting current applications and future challenges.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biohybrid micro- and nanorobots integrate biological and artificial components.
  • These tiny machines offer onboard actuation, sensing, and control capabilities.
  • They are promising for various medical tasks, including targeted drug delivery and cell manipulation.

Purpose of the Study:

  • To provide a comprehensive overview of biohybrid micro- and nanorobots for smart drug delivery.
  • To review different types of biohybrid robots based on their biological components.
  • To discuss their current applications in medicine and healthcare.

Main Methods:

  • Literature review of biohybrid micro- and nanorobots.
  • Detailed examination of various biological components used in their construction.
  • Analysis of their application in active drug delivery systems.

Main Results:

  • A wide array of biohybrid micro- and nanorobots utilizing diverse biological components have been identified.
  • These biohybrid systems demonstrate significant potential for targeted and active drug delivery.
  • Current research showcases their exploitation in advancing medical and healthcare solutions.

Conclusions:

  • Biohybrid micro- and nanorobots represent a significant advancement in smart drug delivery.
  • Key challenges remain in their clinical translation and widespread application.
  • Overcoming these challenges will pave the way for their integration into clinical practice.