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Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Engineering Liganded Gold Nanoclusters as Efficient Theranostic Agents for Cancer Applications
Vlasta Bonačić-Koutecký1,2, Xavier Le Guével3, Rodolphe Antoine4
1Center of Excellence for Science and Technology-Integration of Mediterranean Region (STIM) at, Interdisciplinary Center for Advanced Sciences and Technology (ICAST), University of Split, Poljička cesta 35, 21000, Split, Croatia.
Chembiochem : a European Journal of Chemical Biology
|October 26, 2022
Summary
Luminescent gold nanoclusters show promise for cancer theranostics. Their synthesis, optical properties, and tumor targeting enable sensitive diagnosis and effective therapy.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Luminescent gold nanoclusters are emerging as significant tools in nanomedicine.
- Their unique optical properties and biocompatibility make them attractive for biomedical applications.
Purpose of the Study:
- To highlight key design components for gold nanoclusters as theranostic agents.
- To focus on the application of these nanoclusters in oncology for diagnosis and therapy.
Main Methods:
- Review of synthesis methods for luminescent gold nanoclusters.
- Analysis of optical property tuning for imaging and therapeutic applications.
- Discussion of tumor targeting strategies for enhanced efficacy.
Main Results:
- Gold nanoclusters offer ease of synthesis and tunable optical characteristics.
- Demonstrated potential for sensitive tumor diagnosis.
- Efficacious therapeutic outcomes observed in preclinical studies.
Conclusions:
- Gold nanoclusters are versatile platforms for theranostic applications in oncology.
- Further design optimization can enhance their diagnostic and therapeutic capabilities.
- These nanoclusters represent a promising avenue for integrated cancer care.
