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Updated: Aug 23, 2025

A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
Published on: March 21, 2025
Advances in Photoplethysmography for Personalized Cardiovascular Monitoring
Seamin Kim1, Xiao Xiao2, Jun Chen2
1Department of Physics and Astronomy, University of California, Irvine, CA 92697, USA.
Abstract:
Photoplethysmography (PPG) is garnering substantial interest due to low cost, noninvasiveness, and its potential for diagnosing cardiovascular diseases, such as cardiomyopathy, heart failure, and arrhythmia. The signals obtained through PPG can yield information based on simple analyses, such as heart rate. In contrast, when accompanied by the complex analysis of sophisticated signals, valuable information, such as blood pressure, sympathetic nervous system activity, and heart rate variability, can be obtained. For a complex analysis, a better understanding of the sources of noise, which create limitations in the application of PPG, is needed to get reliable information to assess cardiovascular health. Therefore, this Special Issue handles literature about noises and how they affect the waveform of the PPG caused by individual variations (e.g., skin tone, obesity, age, and gender), physiology (e.g., respiration, venous pulsation, body site of measurement, and body temperature), and external factors (e.g., motion artifact, ambient light, and applied pressure to the skin). It also covers the issues that still need to be considered in each situation.
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