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Nutraceuticals for Complementary Treatment of Multisystem Inflammatory Syndrome in Children: A Perspective from Their
Diego Estrada-Luna1, Elizabeth Carreón-Torres2, Susana González-Reyes3
1Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, Mexico.
Insights
Multisystem inflammatory syndrome in children (MIS-C) linked to SARS-CoV-2 infection presents with inflammation and cardiac issues. This review explores natural compounds as potential treatments to mitigate hyperinflammation damage in MIS-C.
Area of Science:
- Pediatric infectious diseases
- Cardiology
- Immunology
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a serious condition following SARS-CoV-2 infection.
- MIS-C typically manifests 2-4 weeks post-infection with signs of inflammation and cardiac dysfunction.
- Current treatments for MIS-C during the acute phase require further research for safety and effectiveness.
Purpose of the Study:
- To review the potential of natural compounds in managing MIS-C.
- To explore antioxidant and anti-inflammatory properties of natural compounds for MIS-C treatment.
- To identify novel therapeutic interventions for reducing hyperinflammation-related damage in MIS-C.
Main Methods:
- Literature review of existing studies on MIS-C.
- Analysis of research on natural compounds with anti-inflammatory and antioxidant effects.
- Synthesis of findings to propose potential treatment strategies for MIS-C.
Main Results:
- MIS-C is characterized by significant inflammation and potential cardiac complications post-SARS-CoV-2.
- Natural compounds possess antioxidant and anti-inflammatory properties that may counteract MIS-C pathology.
- Evidence suggests natural compounds could mitigate collateral damage from hyperinflammation.
Conclusions:
- Natural compounds offer a promising avenue for novel MIS-C treatments.
- Targeting hyperinflammation with natural agents may reduce MIS-C severity.
- Further research into natural compounds is crucial for developing effective MIS-C interventions.
Abstract:
Multisystem inflammatory syndrome in children (MIS-C) has been widely reported in some children diagnosed with SARS-CoV-2. Clinical signs of MIS-C are manifested at 2 to 4 weeks after SARS-CoV-2 infection, where elevated biomarkers of inflammation and cardiac dysfunction are the hallmark of this syndrome when infection or exposure to SARS-CoV-2 has been confirmed. However, after two years of acknowledgment, MIS-C treatment is still under research to reach safety and effectiveness in the acute phase in children. Therefore, in this review, we discuss the potential use of natural compounds with antioxidant and anti-inflammatory effects to reduce collateral damage caused by hyperinflammation in MIS-C pathology for new research in treatment and interventions.
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