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Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery
Patrícia C Pires1,2,3, Ana Cláudia Paiva-Santos1,2, Francisco Veiga1,2
1Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal.
Pharmaceutics
|October 27, 2022
Summary
Nanometric emulsions show promise for improving antipsychotic drug delivery to the brain. This formulation strategy enhances drug solubility and brain targeting, potentially overcoming limitations in current antipsychotic treatments.
Area of Science:
- Pharmaceutical Sciences
- Neuroscience
- Drug Delivery
Background:
- Antipsychotic drugs often cause disabling side effects and have poor solubility due to their lipophilic nature, hindering high-strength formulation.
- Current treatment strategies face challenges due to these limitations, creating a need for improved drug delivery systems.
Purpose of the Study:
- To review the potential of nanometric emulsions for enhancing antipsychotic drug delivery to the brain.
- To assess the efficacy and safety of nanometric emulsions compared to conventional formulations and administration routes.
Main Methods:
- A comprehensive literature review was conducted to evaluate nanometric emulsions for antipsychotic brain delivery.
- In vivo experiments compared nanometric emulsions with drug solutions and suspensions.
- Intranasal administration was investigated as a preferred route for direct brain transport.
Main Results:
- Nanometric emulsions significantly increased antipsychotic drug solubility (up to 4796-fold).
- Intranasal administration demonstrated direct brain transport, reduced systemic distribution, and improved efficacy and safety.
- In vivo studies showed superior brain targeting with nanometric emulsions compared to solutions/suspensions, attributed to excipients and small droplet size.
Conclusions:
- Nanometric emulsions are a promising strategy to enhance the brain bioavailability of antipsychotic drugs.
- The formulation's excipients and small droplet size contribute to improved drug absorption and brain targeting.
- Intranasal administration via nanometric emulsions offers a potential solution to overcome current treatment gaps in antipsychotic therapy.
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