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Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses
Agathe M G Colmant1, Rémi N Charrel1, Bruno Coutard1
1Unité des Virus Émergents (UVE: Aix-Marseille Univ-IRD 190-Inserm 1207), Marseille, France.
Frontiers in Microbiology
|October 27, 2022
Summary
Jingmenviruses, related to flaviviruses, are emerging viruses with segmented genomes found globally in diverse hosts. Further research is crucial to understand their potential as pandemic threats.
Area of Science:
- Virology
- Emerging Infectious Diseases
Background:
- Jingmenviruses, unclassified Flaviviridae, possess unique segmented genomes.
- The Jingmen tick virus (JMTV) was first identified in China in 2010.
- These viruses show similarities to flaviviruses in protein structure.
Purpose of the Study:
- To review the current understanding of jingmenviruses.
- To highlight their potential as emerging pandemic threats.
- To identify knowledge gaps in jingmenvirus research.
Main Methods:
- Literature review of metagenomics studies.
- Analysis of phylogenetic data.
- Compilation of epidemiological and host association data.
Main Results:
- Jingmenviruses are classified into two clades: tick/vertebrate-associated and insect-associated.
- Detected in various arthropods, vertebrates (including humans), plants, and fungi worldwide.
- Over a hundred human cases of febrile illness linked to jingmenviruses reported in China and Serbia.
Conclusions:
- Jingmenviruses fit the definition of emerging viruses with pandemic potential.
- Significant gaps exist in understanding their replication, transmission, and epidemiology.
- Prioritizing research is essential for preparedness against potential human and veterinary outbreaks.
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