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Circadian clock-based therapeutics in chronic pulmonary diseases
Allan Giri1, Irfan Rahman2, Isaac Kirubakaran Sundar1
1Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Trends in Pharmacological Sciences
|October 27, 2022
Summary
Circadian clock disruption in the lungs is a risk factor for chronic pulmonary diseases. Targeting clock genes offers a novel therapeutic strategy for better treatment outcomes.
Area of Science:
- Biochemistry
- Chronobiology
- Pulmonology
Background:
- The circadian clock regulates physiological and behavioral rhythms.
- Circadian clock disruption in the lungs is linked to chronic pulmonary disease pathobiology.
- Pharmacological manipulation of the circadian clock is a potential therapeutic avenue.
Purpose of the Study:
- To integrate recent findings on circadian clock mechanisms in chronic lung diseases.
- To identify candidate clock genes for therapeutic targeting.
- To propose a roadmap for developing circadian clock-based therapeutics for pulmonary diseases.
Main Methods:
- Literature review and synthesis of preclinical and clinical findings.
- Analysis of candidate clock genes implicated in lung pathobiology.
- Conceptual framework development for therapeutic strategies.
Main Results:
- Circadian clock disruption is a significant factor in chronic pulmonary disease progression.
- Several clock genes present potential targets for pharmacological intervention.
- A roadmap is proposed to guide the development of novel therapeutics.
Conclusions:
- Targeting the circadian clock holds promise for treating chronic pulmonary diseases.
- Further research is needed to translate clock-based discoveries into clinical practice.
- Development of novel therapeutics based on circadian clock modulation could improve patient outcomes.
Keywords:
chronic lung diseasechronotherapycircadian clockcircadian disruptionclock modulatorsclock-based therapyMore Related Videos
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