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Updated: Aug 23, 2025
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database
Cristian Nicolae Sava1,2, Teodora-Maria Bodog3, Larisa Roxana Niulas1,2
1Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Background/Aim:
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of the new variants of the virus, clinical manifestations have been reported in the pediatric population, some with severe evolution. The aim of this study was to identify the laboratory parameters necessary to establish an effective therapy.
Patients And Methods:
In the period from August 2020 to September 2021, 234 pediatric patients met the inclusion criteria and were selected for the study. After confirming the COVID-19 diagnosis, laboratory parameters were analyzed and compared to the severity of the illness.
Results:
Thrombocytopenia (p<0.001), leukocytosis (p<0.001), and lymphopenia (p<0.001) correlated with the severity of the disease. Also, D-dimer values were closely monitored due to the high association of this parameter with an unsatisfactory prognosis and a severe form of the disease.
Conclusion:
The D-dimer values and complete blood count are useful parameters in COVID-19 evaluation in children.
