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Updated: Aug 23, 2025
10:05
Bile Salt-induced Biofilm Formation in Enteric Pathogens: Techniques for Identification and Quantification
Published on: May 6, 2018
12.8K
Clinical Characteristics of Patients with Staphylococcus aureus Bile Infection
Ron Skorochod1, David Raveh2, Yonit Wiener-Well2
1Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel, Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
The Israel Medical Association Journal : IMAJ
|October 30, 2022
Summary
Staphylococcus aureus hepatobiliary infections are poorly understood. This study highlights that hypertension, bedridden status, and nursing home residence are associated with increased mortality in patients with S. aureus biliary infections.
Area of Science:
- Hepatobiliary Medicine
- Infectious Diseases
- Clinical Microbiology
Background:
- The hepatobiliary system is typically sterile, with infections usually involving anaerobes, gram-positive, and gram-negative bacteria.
- Biliary infections caused by Staphylococcus aureus are not well-characterized in existing literature.
Purpose of the Study:
- To describe the clinical features and outcomes of patients experiencing Staphylococcus aureus infection within the hepatobiliary system.
Main Methods:
- A retrospective analysis was conducted on patient medical records.
- Bile cultures positive for Staphylococcus aureus between January 2006 and November 2020 were identified from a hospital database in Israel.
Main Results:
- Twenty-eight cases of Staphylococcus aureus hepatobiliary infection were analyzed.
- Common comorbidities included hypertension, dyslipidemia, chronic kidney disease, and diabetes.
- Methicillin-resistant Staphylococcus aureus (MRSA) accounted for a significant portion of infections, with many being hospital-acquired.
- Hypertension, bedridden status, and nursing home residence were significantly associated with increased in-hospital mortality.
Conclusions:
- Staphylococcus aureus can cause diverse presentations of hepatobiliary infection.
- Clinicians should consider Staphylococcus aureus in patients with risk factors such as hypertension, immobility, or those residing in nursing homes due to their association with higher mortality rates.
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