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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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Novel Therapies in Olfactory Disorders

Michael T Chang1, Zara M Patel1

  • 1Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305 USA.

Current Otorhinolaryngology Reports
|October 31, 2022
PubMed
Abstract

Insights

Novel treatments for olfactory disorders (OD) are emerging, including vitamins, biologics, and regenerative therapies like stem cells. Management is multimodal and personalized for better outcomes.

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Regenerative Medicine

Background:

  • Olfactory disorders (OD) significantly impact quality of life.
  • Current management strategies for OD are often limited in efficacy.

Purpose of the Study:

  • To critically review recent literature on novel treatments for olfactory disorders (OD).
  • To explore emerging therapeutic avenues for improving olfactory function.

Main Methods:

  • Comprehensive literature search of recent studies on olfactory disorder treatments.
  • Critical analysis of emerging therapies, including biologics and regenerative approaches.
  • Evaluation of treatments targeting the neuroregenerative properties of the olfactory epithelium.

Main Results:

  • Emerging therapies include vitamins, supplements, biologics, neuromodulators, and intranasal agents.
  • Investigational treatments harness olfactory epithelium neuroregeneration, such as platelet-rich plasma and stem cell transplantation.
  • Successful OD management requires a multimodal and etiology-tailored approach.

Conclusions:

  • The management of olfactory disorders is evolving with novel therapeutic options.
  • Future treatments will likely leverage the intrinsic neuroregenerative capacity of the olfactory system.
  • Personalized, multimodal treatment strategies are key to successful OD management.
Keywords:
OlfactionOlfactory disordersOlfactory dysfunctionOlfactory lossSmell loss

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