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Updated: Aug 23, 2025
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
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Platelet storage: Progress so far.
Vani Rajashekaraiah1, Magdaline Christina Rajanand2
1Department of Biotechnology, School of Sciences, JAIN (Deemed-to-be University), #34, 1st Cross, JC Road, Bengaluru, 560027, India. vani.rs@jainuniversity.ac.in.
Journal of Thrombosis and Thrombolysis
|October 31, 2022
Summary
Improving platelet storage is vital for transfusions. Antioxidants show promise in extending platelet viability and efficacy during prolonged storage, addressing current limitations.
Area of Science:
- Hematology
- Biotechnology
- Biomedical Engineering
Background:
- Platelet transfusions are critical for emergency surgery and treating bleeding disorders.
- Current platelet storage methods face limitations due to bacterial contamination and storage lesions, impacting shelf life and efficacy.
- Advances in platelet additive solutions and storage materials have improved platelet banking, but efficacy beyond one week remains a challenge.
Purpose of the Study:
- To review critical factors influencing platelet storage quality and viability.
- To explore the evolution of platelet storage strategies over time.
- To emphasize the role and future prospects of antioxidants in enhancing stored platelet efficacy.
Main Methods:
- Literature review of factors affecting platelet storage.
- Analysis of historical developments in platelet storage techniques.
- Examination of the impact of antioxidants on platelet storage solutions.
Main Results:
- Platelet quality and viability are influenced by storage temperature, materials, oxygen, media, and processing methods.
- Cold storage offers rapid hemostasis but does not improve post-transfusion survival.
- Antioxidants have demonstrated potential in enhancing platelet efficacy during extended storage periods.
Conclusions:
- Continued advancements in platelet storage are necessary to meet transfusion demands.
- Antioxidants represent a promising strategy for improving the quality and extending the shelf life of stored platelets.
- Further research into antioxidant mechanisms and optimal dosage is crucial for effective platelet banking.
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