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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Platelet storage: Progress so far.

Vani Rajashekaraiah1, Magdaline Christina Rajanand2

  • 1Department of Biotechnology, School of Sciences, JAIN (Deemed-to-be University), #34, 1st Cross, JC Road, Bengaluru, 560027, India. vani.rs@jainuniversity.ac.in.

Journal of Thrombosis and Thrombolysis
|October 31, 2022
PubMed
Summary
This summary is machine-generated.

Improving platelet storage is vital for transfusions. Antioxidants show promise in extending platelet viability and efficacy during prolonged storage, addressing current limitations.

Keywords:
AntioxidantsCold-stored plateletsPlatelet additive solutionPlatelet storageStorage bags

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Area of Science:

  • Hematology
  • Biotechnology
  • Biomedical Engineering

Background:

  • Platelet transfusions are critical for emergency surgery and treating bleeding disorders.
  • Current platelet storage methods face limitations due to bacterial contamination and storage lesions, impacting shelf life and efficacy.
  • Advances in platelet additive solutions and storage materials have improved platelet banking, but efficacy beyond one week remains a challenge.

Purpose of the Study:

  • To review critical factors influencing platelet storage quality and viability.
  • To explore the evolution of platelet storage strategies over time.
  • To emphasize the role and future prospects of antioxidants in enhancing stored platelet efficacy.

Main Methods:

  • Literature review of factors affecting platelet storage.
  • Analysis of historical developments in platelet storage techniques.
  • Examination of the impact of antioxidants on platelet storage solutions.

Main Results:

  • Platelet quality and viability are influenced by storage temperature, materials, oxygen, media, and processing methods.
  • Cold storage offers rapid hemostasis but does not improve post-transfusion survival.
  • Antioxidants have demonstrated potential in enhancing platelet efficacy during extended storage periods.

Conclusions:

  • Continued advancements in platelet storage are necessary to meet transfusion demands.
  • Antioxidants represent a promising strategy for improving the quality and extending the shelf life of stored platelets.
  • Further research into antioxidant mechanisms and optimal dosage is crucial for effective platelet banking.